The current crisis, caused by the new Corona virus “SARS-CoV-2” and the disease it causes named “coronavirus disease 2019” (abbreviated “COVID-19”) , asks for a quick but safe vaccine development program. The SARS-CoV-2 virus is a betacoronavirus, like MERS-CoV and SARS-CoV. 
Hoffmann et al.  report that the spike proteins of SARS-CoV-2 are involved in the infection and multiplication process of Corona viruses. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming. This mechanism of infection is similar to the Influenza virus, known from seasonal flu and H1N1 Mexican flu. 
The majority of Influenza vaccines are based on an egg-derived manufacturing process and they have a well-established purification process . Although various types of vaccine are on the market, subunit vaccines do not contain live components and are considered as very safe . Purification of the antigens Hemagglutinin and Neuraminidase is important as the removal of non-envelop proteins can contribute to low allergic reactions . In the isolation and purification process of membrane proteins, surfactants like Trition-X100, CTAB, CHAPS, Polysorbate (Tween), Deoxycholate and other detergents are used. The selection for the detergent or a combination of detergents is important during the development phase of vaccines and can also be important in the development of a good manufacturing process. Detergents/surfactants can be very efficient in first solubilizing membrane (spike) proteins in a controlled way, and (in presence of phospholipids) formation of virosome like particles especially in combination with the use of sterile, ready to use hydrophobic beads like CCzorb-PGH4 .
As the new vaccine for SARS-CoV-2 must be accessible as soon as possible and probably will be provided to many people, it could be considered that the basis from a well-known manufacturing method for a high purity vaccine can be used. Even in combination with new technigues like computer-designed nanoparticles and protein building blocks.
Research groups are invited to apply for test samples of sterile, ready to use, hydrophobic beads of CCzorb-PG4H for controlled removal of detergents after solubilization of membrane proteins enabling formation of antigen presenting nanoparticles.
 Centers for Disease Control and Prevention, Coronavirus Disease 2019 (COVID-19), Cases & Latest Updates
 World Health Organization, Health topics on Corona virus; https://www.who.int/health-topics/coronavirus
 Hoffmann et al., SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell (2020), https://doi.org/10.1016/j.cell.2020.02.052
 Saunders-Hastings PR, Krewski D. Reviewing the History of Pandemic Influenza: Understanding Patterns of Emergence and Transmission. Pathogens. 2016;5(4):66. Published 2016 Dec 6. doi:10.3390/pathogens5040066
 Centers for Disease Control and Prevention, Seasonal Influenza (Flu), Prevent Flu,
 WHO e-learning course
 CCzorb-PGH4® Sterile Purified resins and cartridges, suitable for removal of detergents during vaccine production (e.g. Triton-X100, CTAB and Polysorbate 80)
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* Author R. de Boer: https://www.linkedin.com/in/robert-de-boer-37712110/